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SETD8 polyclonal antibody

Rabbit Polyclonal Antibody

  • WB - SETD8 polyclonal antibody ABV11379
    Western blot was performed on nuclear extracts from HeLa cells (HeLa NE, 20 μg) using the antibody diluted 1:1000 in TBS-Tween containing 5% skimmed milk. The molecular weight marker (in kDa) is shown on the right; the location of the protein of interest is indicated by an arrow.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NQR1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 42890 Da
Additional Information
Gene ID 387893
Positive Control Western blot: HeLa cells
Application & Usage Western Blot: 1:1000.
Other Names SET07, SET8, PR/SET07, KMT5A, PR-Set7
Target/Specificity SETD8
Antibody Form Liquid
Appearance Colorless liquid
Formulation In PBS with 0.05% sodium azide and 0.05% ProClin 300.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsSETD8 polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SETD8
Synonyms KMT5A, PRSET7, SET07, SET8
Function Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.
Cellular Location Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes. Colocalized with SIRT2 at mitotic foci. Associates with chromosomes during mitosis; association is increased in a H(2)O(2)-induced oxidative stress- dependent manner. Associates with silent chromatin on euchromatic arms. Not associated with constitutive heterochromatin
Citations (0)

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SETD8 is a histone methyl transferase that specifically monomethylates ‘Lys-20’ of histone H4. This histone modification represents a specific tag for epigenetic transcriptional repression is enriched during mitosis. SETD8 may also play a role in maintaining silent chromatin by preventing the acetylation of the H4 tail.

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$ 185.00
Cat# ABV11379
(40 western blots)
Availability: 5-7days
Bulk Size
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