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WDR5 polyclonal antibody

Rabbit Polyclonal Antibody

  • E - WDR5 polyclonal antibody ABV11380
    To determine the titer, an ELISA was performed using a serial dilution of the antibody. By plotting the absorbance against the antibody dilution (Figure 1), the titer of the antibody was estimated to be 1:12,300.
  • WB - WDR5 polyclonal antibody ABV11380
    Western blot was performed on whole cell lysates of NIH3T3 cells and embryonic stem cells with the antibody diluted 1:1,000 in TBS-Tween containing 5% skimmed milk (Figure 2). The molecular weight marker (in kDa) is shown on the left; the location of the protein of interest is indicated on the right.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P61964
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 36588 Da
Additional Information
Gene ID 11091
Positive Control Western blot: NIH3T3 and embryonic stem cells, ELISA: Peptides.
Application & Usage Western Blot: 1:1000, ELISA: 1:100 – 1:500.
Other Names BIG3, SWD3
Target/Specificity WDR5
Antibody Form Liquid
Appearance Colorless liquid
Formulation In PBS with 0.05% (W/V) sodium azide.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsWDR5 polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name WDR5
Synonyms BIG3
Function Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.
Cellular Location Nucleus
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Wdr5 belongs to the family of WD repeat proteins which are involved in different cellular processes such as cell cycle progression, signal transduction, apoptosis, and gene regulation. It is a component of the Set1A and Set1B histone H3 methylation complexes. These complexes methylate lysine 4 of H3, thereby activating gene transcription. Wdr5 interacts with H3 dimethyl K4, but not with tri or mono methylated H3K4.

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$ 185.00
Cat# ABV11380
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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