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DNMT2 polyclonal antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O14717 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 44597 Da |
| Gene ID | 1787 |
|---|---|
| Positive Control | Western blot: NIH3T3 and embryonic stem cells, ELISA: Peptides. |
| Application & Usage | Western Blot: 1:1000, ELISA: 1:100 – 1:1000 |
| Other Names | TRDMT1, M.HsaIIP, PuMet, RNMT1 |
| Target/Specificity | DNMT2 |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | In PBS with 0.05% (W/V) sodium azide. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | DNMT2 polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRDMT1 |
|---|---|
| Synonyms | DNMT2 {ECO:0000303|PubMed:16424344} |
| Function | Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp) (PubMed:16424344). Has higher activity on tRNA(Asp) modified with queuosine at position 34 (PubMed:30093495). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Ubiquitous. Higher expression in testis, ovary and thymus and at much lower levels in spleen, prostate, colon, small intestine, and peripheral blood leukocytes |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Dnmt2 belongs to the family of DNA cytosine methyltransferases. Dnmt2, however, lacks the large N-terminal regulatory domain common to other eukaryotic methyltransferases and does not methylate CpG in genomic DNA. Instead, it specifically methylates cytosine 38 in the anticodon loop of Asp transfer RNA.
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