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>   home   >   Products   >   Primary Antibodies   >   Cancer   >   JMJD2c polyclonal antibody   

JMJD2c polyclonal antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H3R0
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 119982 Da
Additional Information
Gene ID 23081
Positive Control Western blot: HeLa cells, ELISA: Peptides.
Application & Usage Western Blot: 1:1000, ELISA: 1:50.
Other Names JHDM3c, KDM4c, GASC1
Target/Specificity JMJD2c
Antibody Form Liquid
Appearance Colorless liquid
Formulation In PBS with 0.05% (W/V) sodium azide.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsJMJD2c polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KDM4C
Synonyms GASC1, JHDM3C, JMJD2C, KIAA0780
Function Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00537}
Tissue Location Overexpressed in several esophageal squamous cell carcinomas (ESCs).
Research Areas
Citations (0)

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JMJD2c belongs to the JMJD2 family of histone demethylases which play an important role in the establishment of the histone code. JMJD2c specifically demethylates the trimethylated K9 and K36 of histone H3. It is not able to demethylate K4, K27 and K36 of histone H3, K20 of histone H4, or the mono- and dimethylated H3K9 and H3K36.

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$ 185.00
Cat# ABV11387
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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