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HP1α polyclonal antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P45973
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 22225 Da
Additional Information
Gene ID 23468
Positive Control Western blot: HeLa cells, IF: HeLa cells.
Application & Usage Western Blot: 1:1000, IF: 1:500
Other Names HP1α, HP1A
Target/Specificity HP1α
Antibody Form Liquid
Appearance Colorless liquid
Formulation In PBS with 0.05% sodium azide and 0.05% ProClin 300.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsHP1α polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CBX5
Synonyms HP1A
Function Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Cellular Location Nucleus. Chromosome. Chromosome, centromere. Note=Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase
Citations (0)

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CBX5/HP1 alpha is a component of heterochromatin. It recognizes and binds to histone H3 tails methylated at ‘Lys-9’, leading to epigenetic repression of transcription. HP1 alpha may also interact with lamin B receptor (LBR), thereby contributing to the association of the heterochromatin with the inner nuclear membrane. Further, HP1 alpha is involved in the formation of a functional kinetochore through interaction with MIS12 complex proteins.

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$ 275.00
Cat# ABV11393
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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