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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   PD-1/PDCD1 Antibody   

PD-1/PDCD1 Antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15116
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 31647 Da
Additional Information
Gene ID 5133
Application & Usage WB: 1-2 µg/ml, ELISA: 0.2-1 µg/ml.
Other Names PDCD1, PD1, CD279, SLEB2, hPD-1, hPD-l
Target/Specificity PD-1/PDCD1
Antibody Form Liquid
Appearance Colorless liquid
Formulation In 50 mM Tris, 100 mM glycine, pH 7.0 with trehalose as protectant.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsPD-1/PDCD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDCD1
Synonyms PD1
Function Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen- specific manner. Possible cell death inducer, in association with other factors.
Cellular Location Membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion.

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$ 245.00
Cat# ABV11442
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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