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Cyclin E1 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IF, ICC |
|---|---|
| Primary Accession | P24864 |
| Reactivity | Human, Mouse, Rat, Pig, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 47077 Da |
| Gene ID | 898 |
|---|---|
| Positive Control | WB: HEK293T, mouse brain, PC12, SW626, HeLa, K562, whole cell lysates, IHC: human lung cancer, IC/IF: PC12 cells |
| Application & Usage | WB: 1:500 - 1:1000, IHC: 1:100 – 1:200, IF/IC: 1:100 – 1:500 |
| Other Names | CCNE1, Cyclin Es, Cyclin Et, G1/S-specific cyclin-E1 |
| Target/Specificity | Cyclin E1 |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 1 mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Cyclin E1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CCNE1 |
|---|---|
| Synonyms | CCNE |
| Function | Essential for the control of the cell cycle at the G1/S (start) transition. |
| Cellular Location | Nucleus. |
| Tissue Location | Highly expressed in testis and placenta. Low levels in bronchial epithelial cells. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Cyclin E1 is a regulatory subunit of the CDK2 kinase. It is central for the regulation of the G1/S transition and its abundance is tightly regulated throughout the cell cycle via ubiquitination. Cyclin E has been the subject of intense study in relation to tumorigenesis and cancer management and prognosis. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.
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