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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   Cyclin F Antibody   

Cyclin F Antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P41002
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 87640 Da
Additional Information
Gene ID 899
Positive Control WB: HEK293T, mouse liver, rat liver, whole cell lysates, IHC: human breast cancer
Application & Usage WB: 1:500 - 1:1000, IHC: 1:100 – 1:200.
Other Names F-box only protein 1, CCNF, FBX1, FBXO1, G2/mitotic-specific cyclin-F
Target/Specificity Cyclin F
Antibody Form Liquid
Appearance Colorless liquid
Formulation 1 mg/ml in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsCyclin F Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms FBX1, FBXO1
Function Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.
Cellular Location Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110 Also localizes to the nucleus
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Cyclin F is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is ubiquitously expressed in human cells but fluctuates dramatically through the cell cycle, peaking in G2 like cyclin A and decreasing prior to decline of cyclin B. Cyclin F exhibits regulated subcellular localization, being localized in the nucleus in most cells, with a significant percentage of cells showing only perinuclear staining.

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$ 190.00
Cat# ABV11444
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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