|Calculated MW||14726 Da|
|Positive Control||Western Blot: human BNP|
|Application & Usage||Western blot: 1-4 µg|
|Other Names||NPPB, Natriuretic Peptide Precursor B, BNP, B-type Natriuretic Peptide|
|Formulation||100 µg (0.5 mg/ml) of antibody in PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin®, and 50 % glycerol.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||BNP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.|
|Tissue Location||Brain and also in atria, but at much lower levels than ANP|
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Provided below are standard protocols that you may find useful for product applications.
Natriuretic Peptide Precursor B acts as a cardiac hormone with a variety of biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. It is thought to play a key role in cardiovascular homeostasis. It helps to restore the body's salt and H₂O balance and improves heart function
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