|Reactivity||Human, Mouse, Rat|
|Calculated MW||45113 Da|
|Other Names||Sirtuin 7 (Silent mating type information regulation 2, homolog) 7 (S. cerevisiae) (Sirtuin 7 (Silent mating type information regulation 2, homolog) 7 (S. cerevisiae) (Predicted), isoform CRA_b)|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti- SIRT7 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Precautions||SIRT7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation (By similarity).|
|Cellular Location||Cytoplasm. Nucleus, nucleolus. Note=Located close to the nuclear membrane when in the cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis.|
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SIRT7 is a member of the sirtuin family of proteins (Sir2-like proteins). All Sir2-like proteins are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins are not fully understood yet. Recent studies s µggested that bacterial, yeast and mammalian sirtuins are able to metabolize NAD and may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.
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