|Reactivity||Human, Mouse, Rat, Monkey|
|Calculated MW||30660 Da|
|Other Names||Seven in absentia homolog 3, Siah-3, SIAH3|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-SALL1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Precautions||SIAH3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Negative regulator of PARK2 translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PARK2 targeting to dysfunctional depolarized mitochondria.|
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Provided below are standard protocols that you may find useful for product applications.
SIAH-3 is a member of the seven in absentia homolog protein family. SIAH3 contains one SIAH-type zinc finger and is encoded by a gene located on human chromosome 13. SIAH families are components that mediate ubiquitination and subsequent proteasomal degradation of target proteins.
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