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TRIM71 Antibody
Purified Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q2Q1W2 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 93385 Da |
| Gene ID | 131405 |
|---|---|
| Other Names | Protein lin-41 homolog |
| Target/Specificity | TRIM71 |
| Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit anti-TRIM71 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal. |
| Handling | The antibody solution should be gently mixed before use. |
| Background Descriptions | |
| Precautions | TRIM71 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRIM71 (HGNC:32669) |
|---|---|
| Synonyms | LIN41 |
| Function | E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (PubMed:23125361). Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity). Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (PubMed:28431233). |
| Cellular Location | Cytoplasm, P-body |
| Tissue Location | Specifically expressed in testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
TRIM71 is similar to the C.elegans homolog protein Lin41. TRIM71 is a target of the microRNA let-7 and is likely to play a role in mammalian development. From recent research, TRIM71 has been indicated as a ubiqutin ligase that can interact with Dicer and Argonaut proteins Ago1, Ago2 and Ago4.
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