|Reactivity||Human, Mouse, Rat|
|Calculated MW||93385 Da|
|Other Names||Protein lin-41 homolog|
|Format||100 µg (0.5 mg/ml) affinity purified rabbit anti-TRIM71 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Precautions||TRIM71 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity).|
|Cellular Location||Cytoplasm, P-body.|
|Tissue Location||Specifically expressed in testis.|
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Provided below are standard protocols that you may find useful for product applications.
TRIM71 is similar to the C.elegans homolog protein Lin41. TRIM71 is a target of the microRNA let-7 and is likely to play a role in mammalian development. From recent research, TRIM71 has been indicated as a ubiqutin ligase that can interact with Dicer and Argonaut proteins Ago1, Ago2 and Ago4.
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