|Reactivity||Human, Mouse, Rat|
|Calculated MW||40737 Da|
|Other Names||Ribonucleoside-diphosphate reductase subunit M2 B, 126.96.36.199, TP53-inducible ribonucleotide reductase M2 B, p53-inducible ribonucleotide reductase small subunit 2-like protein, p53R2, RRM2B, P53R2|
|Formulation||100 µg (0.5 mg/ml) immunoaffinity purified rabbit anti-p53R2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% sodium azide.|
|Handling||The antibody solution should be gently mixed before use.|
|Precautions||p53R2 Polyclonal Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.|
|Cellular Location||Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus in response to DNA damage|
|Tissue Location||Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma|
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Provided below are standard protocols that you may find useful for product applications.
p53R2 is a p53 inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase. p53R2 is induced by reagents (e.g., ultraviolet and g-irradiation) that can cause DNA damages and then functions in the p53 checkpoint for repair of damaged DNA. The isoform of the p53 family member p73 also induces p53R2 expression.
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