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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PUMA/bbc3 Antibody   

PUMA/bbc3 Antibody

Purified Rabbit Polyclonal Antibody

  • WB - PUMA/bbc3 Antibody ABV11526
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BXH1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 20532 Da
Additional Information
Gene ID 27113
Other Names JFY1; PUMA; FLJ42994; BBC3
Target/Specificity PUMA
Format 100 µg (0.5 mg/ml) affinity purified rabbit anti-PUMA polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Background Descriptions
PrecautionsPUMA/bbc3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BBC3
Synonyms PUMA
Function Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis.
Cellular Location Mitochondrion Note=Localized to the mitochondria in order to induce cytochrome c release
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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PUMA (p53 upregulated modulator of apoptosis) is one of the pro-apoptotic Bcl-2 family members which are also transcriptional targets of p53. PUMA gene encodes two BH3 domain-containing proteins termed PUMA-α and PUMA-β. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.

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$ 265.00
Cat# ABV11526
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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