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MMP-3 Antibody
Purified Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IP |
|---|---|
| Primary Accession | P08254 |
| Reactivity | Human, Mouse, Rat |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | Goat IgG |
| Calculated MW | 53977 Da |
| Gene ID | 4314 |
|---|---|
| Other Names | STR1 , MGC126102 , STMY1 , Transin-1 , MGC126102 , MGC126103 , MGC126104 , EC 3.4.24.17 , SL-1 , Matrix metalloproteinase |
| Target/Specificity | MMP-3 |
| Formulation | 100 µg (0.5 mg/ml) antigen affinity purified goat polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% sodium azide. |
| Handling | The antibody solution should be gently mixed before use. |
| Background Descriptions | |
| Precautions | MMP-3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MMP3 |
|---|---|
| Synonyms | STMY1 |
| Function | Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9 (PubMed:11029580, PubMed:1371271). Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway (PubMed:2383557). Acts also intracellularly (PubMed:22265821). For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha- synuclein/SNCA cleavage (PubMed:21330369). In addition, plays a role in immune response and possesses antiviral activity against various viruses such as vesicular stomatitis virus, influenza A virus (H1N1) and human herpes virus 1 (PubMed:35940311). Mechanistically, translocates from the cytoplasm into the cell nucleus upon virus infection to influence NF-kappa-B activities (PubMed:35940311). |
| Cellular Location | Secreted, extracellular space, extracellular matrix. Nucleus. Cytoplasm |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10, and MMP-11 activates procollagenase.
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