|Application ||WB, IHC, IP|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||53412 Da|
|Other Names||Neutrophil collagenase, 22.214.171.124, Matrix metalloproteinase-8, MMP-8, PMNL collagenase, PMNL-CL, MMP8, CLG1|
|Formulation||100 µg (0.5 mg/ml) protein A affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Precautions||MMP-8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Can degrade fibrillar type I, II, and III collagens.|
|Cellular Location||Cytoplasmic granule. Secreted, extracellular space, extracellular matrix. Note=Stored in intracellular granules|
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Provided below are standard protocols that you may find useful for product applications.
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. Unlike other members of the MMP family, MMP-8 is expressed exclusively in inflammatory conditions. MMP-8 is also the predominant collagenase expressed in ulcers and healing wounds.
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