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TROY Polyclonal Antibody
Purified Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9NS68 |
| Reactivity | Human, Mouse, Rat |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 46015 Da |
| Gene ID | 55504 |
|---|---|
| Other Names | Tumor necrosis factor receptor superfamily member 19, TRADE, Toxicity and JNK inducer, TNFRSF19, TAJ, TROY |
| Target/Specificity | TROY |
| Formulation | 100 mg (0.2 mg/ml) goat polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% sodium azide. |
| Handling | The antibody solution should be gently mixed before use. |
| Background Descriptions | |
| Precautions | TROY Polyclonal Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TNFRSF19 |
|---|---|
| Synonyms | TAJ, TROY |
| Function | Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death. |
| Cellular Location | Membrane; Single-pass type I membrane protein |
| Tissue Location | Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes |
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Provided below are standard protocols that you may find useful for product applications.
Background
TROY (also designated TAJ), a member of the TNFR superfamily, exists as several isoforms that vary in functions. Full length TROY contains a cytoplasmic tail, which recruits tumor necrosis factor receptor-associated factor (TRAF) 2. The interaction between TROY and TRAF2 promotes cell survival through the NFκB signaling pathway. One truncated version of TROY, designated TNFRSF19, contains a shortened cytoplasmic tail, which prevents TNFRSF19 from activating the NFκB signal transduction pathway.
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