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BCMA (TNFRSF17) Antibody

Purified Rabbit Polyclonal Antibody

     
  • WB - BCMA (TNFRSF17) Antibody ABV11544-30
    Western blot with human BCMA antibody: lane1.22ug mouse muscle lysate; lane2.60ug rat kidney lysate; lane3.50ug K562 lysate; lane4.50ug U937 lysate
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q02223
Reactivity Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype rabbit IgG
Calculated MW 20165 Da
Additional Information
Gene ID 608
Other Names B Cell Maturation, BCM, CD269, TNFRSF17, 109545, Q02223, BCMA
Target/Specificity BCMA (TNFRSF17)
Formulation 100 µg (0.5 mg/ml) of antibody in PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin®, and 50 % glycerol.
Handling The antibody solution should be gently mixed before use.
Background Descriptions
PrecautionsBCMA (TNFRSF17) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNFRSF17
Synonyms BCM, BCMA
Function Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
Cellular Location Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein Note=Perinuclear Golgi-like structures
Tissue Location Expressed in mature B-cells, but not in T-cells or monocytes
Research Areas
Citations (0)
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Background

BCMA, also named TNFRSF17, is a receptor for tnfsf13b/blys/baff and tnfsf13/april. TNFRSF17 promotes b-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 activates nf-κ-b and jnk. TNFRSF17 is a member of the TNF-receptor superfamily. TNFRSF17 is expressed in mature B lymphocytes, and is involved in B cell development and autoimmune response. TNFRSF17 specifically binds to the tumor TNFSF13B/TALL-1/BAFF, which causes NF-κB and MAPK8/JNK activation. TNFRSF17 binds to a variety of TRAF family members, and therefore transduces signals for cell survival and proliferation. TNFRSF17 is a type III membrane protein having 1 extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand superfamily. BCMA expression has been found in immune organs. TNFRSF17 appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells.

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Discontinued
Cat# ABV11544-30
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