|Reactivity||Human, Mouse, Rat|
|Calculated MW||30645 Da|
|Other Names||stem cell factor, Mast cell growth factor, MGF, C-kit ligand|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-mouse SCF polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Precautions||SCF Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||Kitl, Mgf, Sl, Slf|
|Function||Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Soluble KIT ligand: Secreted.|
|Tissue Location||Expressed in the cochlea.|
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Provided below are standard protocols that you may find useful for product applications.
Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. SCF stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors in bone marrow cultures.
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