|Application ||WB, IP|
|Calculated MW||12467 Da|
|Other Names||C motif chemokine 1, Cytokine SCM-1, Small-inducible cytokine C1|
|Formulation||100 µg (0.5 mg/ml) Protein A purified rabbit anti-mouse Lymphotactin polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Precautions||Lymphotactin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||Lptn, Ltn, Scyc1|
|Function||Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.|
|Tissue Location||Expressed in activated CD8(+) T cells. In the thymus, expressed by medullary thymic epithelial cells|
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Provided below are standard protocols that you may find useful for product applications.
Lymphotactin is the only C chemokine so far identified which has a single cysteine residue near the amino terminus. It has 114 amino acids with a 22 amino acids signal peptide. It is produced in activated CD8+ T cells and NK cells. Lymphotactin attracts both T lymphocytes and NK cells.
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