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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   Midkine Antibody   

Midkine Antibody

Purified Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21741
Other Accession NP_002382.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 15585 Da
Additional Information
Gene ID 4192
Other Names MK, MK1, MK-1, MK 1, midkine
Target/Specificity Midkine
Format 100 µg (0.5 mg/ml) antigen affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal.
Handling The antibody solution should be gently mixed before use.
Background Descriptions
PrecautionsMidkine Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MDK
Synonyms MK1, NEGF2
Function Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity).
Cellular Location Secreted.
Tissue Location Expressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions
Research Areas
Citations (0)

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Human Midkine (MK) is a new member of the heparin-binding neurotrophic factor family. MK and PTN (Pleiotrophin) are structural homologs, and are highly conserved among species. MK plays important roles in development and carcinogenesis and has several important biological effects, including promotion of neurite extension and neuronal survival. Human midkine is a 13.4 kDa protein, comprising of 123 amino acid residues.

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$ 245.00
Cat# ABV11600
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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