|Calculated MW||46471 Da|
|Other Names||VEGF C, Vascular Endothelial Growth Factor C , Vascular endothelial growth factor-related protein C; VRP|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-murine VEGF-C polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Precautions||VEGF-C Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.|
|Tissue Location||Expressed in adult heart, brain, spleen, lung, liver, skeletal muscle, kidney, testis and intestine with higher levels in heart, brain and kidney. Isoform 4 levels are very low Isoform 3 is mostly expressed in liver and has reduced expression level in other tissues. Isoform 2 is mostly expressed in brain and kidney, although a lower level expression in other tissues is also detectable.|
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Vascular Endothelial Growth Factor-C (VEGF-C) is a 125 amino acid protein that plays an important role in angiogenesis and many other biological processes. Human VEGF-C exhibits about 85% homology with murine VEGF-C.
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