BMP-1 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | P13497 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 111249 Da |
Gene ID | 649 |
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Other Names | Bone morphogenetic protein 1, BMP-1, 3.4.24.19, Mammalian tolloid protein, mTld, Procollagen C-proteinase, PCP, BMP1, PCOLC |
Target/Specificity | BMP-1 |
Formulation | 100 µg (0.5 mg/ml) immunoaffinity purified rabbit anti-BMP-1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Background Descriptions | |
Precautions | BMP-1 Polyclonal Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | BMP1 |
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Synonyms | PCOLC |
Function | Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins (PubMed:33206546). Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair (PubMed:33169406, PubMed:32636307). Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross- links in collagen and elastic fibers (PubMed:31152061, PubMed:33206546). Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation (PubMed:32636307). |
Cellular Location | Golgi apparatus, trans-Golgi network. Secreted, extracellular space, extracellular matrix. Secreted. Note=Co-localizes with POSTN in the Golgi. |
Tissue Location | Ubiquitous. |
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Provided below are standard protocols that you may find useful for product applications.
Background
BMP-1 is an extracellular zinc endopeptidase of the Astacin family. Defects in BMP-1 are thought to lead to aberrant collagen processing and connective tissue disorders. Many forms of BMP-1 have been reported, with varying truncation at the carboxyterminal end. The long form of BMP-1 is most similar to the Tolloid-like proteins, which have extra EGF-like and CUB domains.
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