|Calculated MW||111249 Da|
|Other Names||Bone morphogenetic protein 1, BMP-1, 22.214.171.124, Mammalian tolloid protein, mTld, Procollagen C-proteinase, PCP, BMP1, PCOLC|
|Format||100 µg (0.5 mg/ml) immunoaffinity purified rabbit anti-BMP-1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Precautions||BMP-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX.|
|Cellular Location||Golgi apparatus, trans-Golgi network. Secreted, extracellular space, extracellular matrix. Note=Co- localizes with POSTN in the Golgi.|
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Provided below are standard protocols that you may find useful for product applications.
BMP-1 is an extracellular zinc endopeptidase of the Astacin family. Defects in BMP-1 are thought to lead to aberrant collagen processing and connective tissue disorders. Many forms of BMP-1 have been reported, with varying truncation at the carboxyterminal end. The long form of BMP-1 is most similar to the Tolloid-like proteins, which have extra EGF-like and CUB domains.
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