|Calculated MW||44768 Da|
|Other Names||BMP8, BMP-8, BMP 8, bone morphogenetic protein 8|
|Formulation||100 mg (0.5 mg/ml) antigen affinity purified goat anti-BMP-8 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol and 0.02% Thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Precautions||BMP-8 Polyclonal Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
BMPs (bone morphogenetic proteins) belong to the TGF-beta superfamily of structurally related signaling proteins. Members of this superfamily are widely represented throughout the animal kingdom and have been implicated in a variety of developmental processes. Proteins of the TGF-beta superfamily are disulfide-linked dimmers composed of two 12-15 kDa polypeptide chains. As implied by their name, BMPs initiate, promote and regulate bone development, growth, remodeling and repair. BMP-8 (also designated OP-2) is thought to be involved in early development, as detectable expression has not been found in adult organs.
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