Visfatin Antibody
Purified Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q80Z29 |
Reactivity | Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 55438 Da |
Gene ID | 297508 |
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Other Names | Nampt, Nicotinamide phosphoribosyltransferase, Pre-B-cell colony-enhancing factor 1 homolog, PBEF, visceral fat-derived hormone |
Target/Specificity | Visfatin |
Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit anti-rat Visfatin polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA and 0.01% thimerosal |
Handling | The antibody solution should be gently mixed before use. |
Background Descriptions | |
Precautions | Visfatin Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Nampt |
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Synonyms | Pbef1 |
Function | Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1- mediated suppression. |
Cellular Location | Nucleus. Cytoplasm. Secreted {ECO:0000250|UniProtKB:P43490} Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100- fold higher concentrations compared to maternal serum {ECO:0000250|UniProtKB:P43490} |
Tissue Location | Expressed in various tissues. At the highest level in liver and at the second highest in heart. The amount is higher in heart than in lung. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Visfatin is a cytokine highly expressed in visceral fat and blood. This protein has also been reported to be a cytokine (PBEF) that promotes B cell maturation and inhibits neutrophil apoptosis. Visfatin is tho µght to have insulin-like activities and is able to bind insulin receptor and thus, may lead to lowering blood glucose levels.
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