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TRIB1 Antibody

Purified Rabbit Polyclonal Antibody

  • WB - TRIB1 Antibody ABV11641
    Western blot analysis of anti-TRIB1 pAb in T47D cell line lysate (35 ug/lane). TRIB1 was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96RU8
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 41009 Da
Additional Information
Gene ID 10221
Other Names Tribbles homolog 1, TRB-1, G-protein-coupled receptor-induced gene 2 protein, GIG-2, SKIP1, TRIB1
Target/Specificity TRIB1
Format In PBS with 0.09% (W/V) sodium azide
Handling The antibody solution should be gently mixed before use.
Background Descriptions
PrecautionsTRIB1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIB1 (HGNC:16891)
Function Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity.
Tissue Location Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow
Research Areas
Citations (0)

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TRIB1 antibody, also called gprotein coupled receptor induced, skip1, gig2, c8fwATP, functions in protein binding, protein kinase inhibitor activity, and protein serine/threonine kinase activities. Overexpression of TRIB1 in HeLa cells repressed the basal activity of the IL8 promoter by inhibiting AP1 activity. Overexpression of TRIB1 inhibited oncogenic Ras -driven AP1 activation and MEKK1-mediated AP1 activation. ERK activation was enhanced by TRIB1. Coimmunoprecipitation and yeast 2-hybrid assays showed that MEK1 interacted with both TRIB1 and TRIB3, and MKK4 interacted specifically with TRIB1. Cotransfection of MKK4 enhanced the level of TRIB1, indicating that the TRIB-MAPKK interaction stabilized TRIB1

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$ 265.00
Cat# ABV11641
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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