|Calculated MW||72314 Da|
|Other Names||Breast Cancer Resistance Protein, BCRP1, ATP-binding cassette sub-family G member 2, ATP binding cassette sub family G (WHITE) member 2, ABCG2, Mitoxantrone resistance associated protein, MXR, MXR1|
|Format||Each vial contains 5mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3, 0.05 mg Thimerosal|
|Handling||The vial should be centrifuged to collect the lyophilized solid before reconstituting|
|Precautions||BCRP (ABCG2) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ABCP, BCRP, BCRP1, MXR|
|Function||High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in placenta. Low expression in small intestine, liver and colon.|
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Provided below are standard protocols that you may find useful for product applications.
BCRP, also called ABCG2, is encoded by the ABCG2 gene. BCRP is a well-characterized ABC-transporter (which limits uptake or mediates efflux of a wide variety of drugs, carcinogens, dietary toxins across cellular membranes). It is an ATP-dependent pump with broad substrate specificity. Significant expression has been observed in the placenta and it has been shown to have a role in protecting the fetus from xenobiotics in the maternal circulation. It plays protective roles in blocking absorption at the apical membrane of the intestine, and at the blood-testis barrier, the blood–brain barrier and the membranes of hematopoietic progenitor and other stem cells. At the apical membranes of the liver and kidney, it enhances excretion of xenobiotics. In the lactating mammary gland, it has a role on excreting vitamins such as riboflavin and biotin into milk.
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