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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   BCRP (ABCG2) Antibody   

BCRP (ABCG2) Antibody

Purified Rabbit Polyclonal Antibody

     
  • WB - BCRP (ABCG2) Antibody ABV11644
    Lane1: Hela cell lysate; Lane2: SW620 cell lysate; Lane3: MCF-7 cell lysate; Lane4: SKOV cell lysate; Lane5: Jurkat cell lysate
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9UNQ0
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 72314 Da
Additional Information
Gene ID 9429
Other Names Breast Cancer Resistance Protein, BCRP1, ATP-binding cassette sub-family G member 2, ATP binding cassette sub family G (WHITE) member 2, ABCG2, Mitoxantrone resistance associated protein, MXR, MXR1
Target/Specificity BCRP (ABCG2)
Format Each vial contains 5mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3, 0.05 mg Thimerosal
Handling The vial should be centrifuged to collect the lyophilized solid before reconstituting
Background Descriptions
PrecautionsBCRP (ABCG2) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ABCG2
Synonyms ABCP, BCRP, BCRP1, MXR
Function High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.
Cellular Location Cell membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein
Tissue Location Highly expressed in placenta. Low expression in small intestine, liver and colon.
Research Areas
Citations (0)

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Background

BCRP, also called ABCG2, is encoded by the ABCG2 gene. BCRP is a well-characterized ABC-transporter (which limits uptake or mediates efflux of a wide variety of drugs, carcinogens, dietary toxins across cellular membranes). It is an ATP-dependent pump with broad substrate specificity. Significant expression has been observed in the placenta and it has been shown to have a role in protecting the fetus from xenobiotics in the maternal circulation. It plays protective roles in blocking absorption at the apical membrane of the intestine, and at the blood-testis barrier, the blood–brain barrier and the membranes of hematopoietic progenitor and other stem cells. At the apical membranes of the liver and kidney, it enhances excretion of xenobiotics. In the lactating mammary gland, it has a role on excreting vitamins such as riboflavin and biotin into milk.

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$ 325.00
Cat# ABV11644
Size:
Quantity:
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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