|Calculated MW||10903 Da|
|Other Names||BPTI, Basic protease inhibitor, Pancreatic trypsin inhibitor|
|Formulation||100 µg (0.5 mg/ml) of antibody in PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin®, and 50 % glycerol.|
|Handling||The antibody solution should be gently mixed before use.|
|Precautions||Aprotinin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.|
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Provided below are standard protocols that you may find useful for product applications.
Aprotinin inhibits the activity of several proteolytic enzymes such as chymotrypsin, kallikrein, plasmin and trypsin. It is present in blood and in most tissues, with a high concentration in lung, inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis. In platelets, Aprotinin reduces glycoprotein loss (e.g., GpIb, GpIIb/IIIa), while in granulocytes it prevents the expression of pro-inflammatory adhesive glycoproteins. Aprotinin is a natural proteinase inhibitor polypeptide consisting of fifty-eight amino acids arranged in a single polypeptide chain, cross-linked by three disulfide bridges.
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