Alpha1 Antitrypsin Antibody
Purified Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | P01009 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | rabbit IgG |
Calculated MW | 46737 Da |
Gene ID | 5265 |
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Other Names | Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Serpin A1, AAT, PI |
Target/Specificity | Alpha1 Antitrypsin |
Formulation | 100 µg (0.5 mg/ml) of antibody in PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin®, and 50 % glycerol. |
Handling | The antibody solution should be gently mixed before use. |
Background Descriptions | |
Precautions | Alpha1 Antitrypsin Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SERPINA1 (HGNC:8941) |
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Synonyms | AAT, PI |
Function | Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. |
Cellular Location | Secreted. Endoplasmic reticulum. Note=The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum |
Tissue Location | Ubiquitous. Expressed in leukocytes and plasma. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Alpha 1 Antitrypsin is an acute-phase plasma protein found at 290 mg per 100 ml. It functions as a serine protease inhibitor with targets like elastase, plasmin, collagenase, thrombin, leucocyte proteases, trypsin, chymotrypsin, and plasminogen activator. Clinically, its deficiency is associated with two major diseases: pulmonary emphysema and early onset/juvenile hepatic cirrhosis. It is elevated in inflammatory conditions, malignancies, liver disease and pregnancy and also after surgical trauma and use of oral contraceptives. The simultaneous quantitative determination of alpha-1-PI and ceruloplasmin permits differential diagnosis of liver afflictions. Rise in alpha 1 antitrypsin occurs as an acute phase response to tissue necrosis and inflammation.
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