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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   Alpha1 Antitrypsin Antibody   

Alpha1 Antitrypsin Antibody

Purified Rabbit Polyclonal Antibody

  • WB - Alpha1 Antitrypsin Antibody ABV11649
    Western blot with human alpha1 anti-trypsin antibody: Lane1: 22ug M.muscle; Lane2: 60ug R.kidney; Lane3: 1ug Human serum; Lane4: 2ng H alpha1 antitrypsin; Lane5: 10ng H alpha1 antitrypsin; Lane6: 50ng H alpha1 antitrypsin.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01009
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype rabbit IgG
Calculated MW 46737 Da
Additional Information
Gene ID 5265
Other Names Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Serpin A1, AAT, PI
Target/Specificity Alpha1 Antitrypsin
Format 100 µg (0.5 mg/ml) of antibody in PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin®, and 50 % glycerol.
Handling The antibody solution should be gently mixed before use.
Background Descriptions
PrecautionsAlpha1 Antitrypsin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms AAT, PI
Function Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.
Cellular Location Secreted. Endoplasmic reticulum. Note=The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum
Tissue Location Ubiquitous. Expressed in leukocytes and plasma.
Research Areas
Citations (0)

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Alpha 1 Antitrypsin is an acute-phase plasma protein found at 290 mg per 100 ml. It functions as a serine protease inhibitor with targets like elastase, plasmin, collagenase, thrombin, leucocyte proteases, trypsin, chymotrypsin, and plasminogen activator. Clinically, its deficiency is associated with two major diseases: pulmonary emphysema and early onset/juvenile hepatic cirrhosis. It is elevated in inflammatory conditions, malignancies, liver disease and pregnancy and also after surgical trauma and use of oral contraceptives. The simultaneous quantitative determination of alpha-1-PI and ceruloplasmin permits differential diagnosis of liver afflictions. Rise in alpha 1 antitrypsin occurs as an acute phase response to tissue necrosis and inflammation.

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$ 265.00
$ 89.00
Cat# ABV11649
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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