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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   Antithrombin III Antibody   

Antithrombin III Antibody

Purified Rabbit Polyclonal Antibody

  • WB - Antithrombin III Antibody ABV11652
    Western blot with human anti-thrombin Ⅲ antibody: lane1: R.kidney lysate 60ug; lane2: M.muscle lysate 66ug; lane3: human serum 5.2ug; lane4: Human antithrombin Ⅲ 2ng; lane5: Human antithrombin Ⅲ 10ng; lane6: Human antithrombin Ⅲ 50ng.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01008
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype rabbit IgG
Calculated MW 52602 Da
Additional Information
Gene ID 462
Other Names SERPINC1
Target/Specificity Antithrombin III
Format 100 µg (0.5 mg/ml) of antibody in PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin®, and 50 % glycerol.
Handling The antibody solution should be gently mixed before use.
Background Descriptions
PrecautionsAntithrombin III Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms AT3
Function Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.
Cellular Location Secreted, extracellular space.
Tissue Location Found in plasma.
Research Areas
Citations (0)

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SerpinC1, also known as antithrombin III (AT III), is a member of the serpin superfamily of serine protease inhibitors, and has been found to be a marker for disseminated intravascular coagulation (DIC) and to be of prognostic significance in septic patients. SerpinC1 synthesized in the liver is the principal plasma serpin of blood coagulation proteases and inhibits thrombin and other factors such as Xa by the formation of covalently linked complexes. Thus it is one of the most important coagulation inhibitors and the fundamental enzyme for the therapeutical action of heparin. In common with SerpinA5 and D1, the inhibitory activity of SerpinC1 undergoes a dramatic increase in the presence of heparin and other glycosaminoglycans. ATIII mediates the promotion of prostaglandin release, an inhibitor of leucocyte activation and downregulator of many proinflammatory cytokines. Antithrombin III exerts anti-inflammatory properties in addition to its anti-coagulative mechanisms. In animal models of sepsis, ATIII affected cytokine plasma concentrations with a decrease of pro-inflammatory cytokines. The deficiency or functional abnormality of ATIII may result in an increased risk of thromboembolic disease, such as deep vein thrombosis and pulmonary embolism. In addition, it has been reported that SerpinC1 can alter or influence inflammatory processes via inhibition of NF-κB activation or actin polymerization. Antithrombin III is found in normal serum at 15 mg per 100 ml. Found at higher levels in plasma than in serum because of complexing with thrombin during coagulation. Clinically, reduced levels are indicative of hypercoagulability.

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$ 265.00
$ 89.00
Cat# ABV11652
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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