|Reactivity||Human, Mouse, Rat|
|Calculated MW||77329 Da|
|Other Names||TGM2, Protein-glutamine gamma-glutamyltransferase 2, Tissue transglutaminase, TG, TGC, TGase C, Transglutaminase H, TGase H, TGase-2|
|Formulation||100 µg (0.5 mg/ml) of antibody in PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin®, and 50 % glycerol.|
|Handling||The antibody solution should be gently mixed before use.|
|Precautions||Transglutaminase-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.|
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Provided below are standard protocols that you may find useful for product applications.
Tissue transglutaminase, a 78-kDa calcium dependent enzyme (EC 220.127.116.11), is found both in the intracellular and the extracellular spaces of various types of tissues. TG2 crosslinks proteins between the ε-amino group of a lysine residue and the γ-carboxamide group of glutamine residue, creating an inter- or intramolecular bond that is highly resistant to proteolysis (protein degradation). TG2 also possesses deamidation, GTP-binding/hydrolyzing, and isopeptidase activities. Intracellular TG2 is thought to play an important role in apoptosis, while extracellular TG2 has been linked to cell adhesion, ECM stabilization, wound healing, receptor signaling, cellular proliferation, and cellular motility.
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