|Application ||WB, IHC, E|
|Calculated MW||45159 Da|
|Other Names||CASP-1, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, ICE, IL-1 beta-converting enzyme, p45, IL1BC, IL1BCE, CASP1|
|Formulation||50 µl purified antibody supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide|
|Handling||The antibody solution should be gently mixed before use.|
|Precautions||Cleaved-Caspase-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.|
|Tissue Location||Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.|
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Provided below are standard protocols that you may find useful for product applications.
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Cleaved-caspase-1 (D210) detects levels of fragment of activated Caspase-1 protein resulting from cleavage adjacent to D210.
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