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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   Cleaved-Caspase-1 Antibody   

Cleaved-Caspase-1 Antibody

Purified Rabbit Polyclonal Antibody

     
  • WB - Cleaved-Caspase-1 Antibody ABV11663
    Western blot analysis of anti-cleaved-caspase-1 with 3T3 cell lysate. Native form (hollow arrow) and cleaved form (filled arrow) of caspase-1 was deteced using the purified antibody.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, E
Primary Accession P29466
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 45159 Da
Additional Information
Gene ID 834
Other Names CASP-1, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, ICE, IL-1 beta-converting enzyme, p45, IL1BC, IL1BCE, CASP1
Target/Specificity Cleaved Caspase-1
Format 50 µl purified antibody supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Handling The antibody solution should be gently mixed before use.
Background Descriptions
PrecautionsCleaved-Caspase-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CASP1
Synonyms IL1BC, IL1BCE
Function Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
Cellular Location Cytoplasm.
Tissue Location Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.
Research Areas
Citations (0)

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Background

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Cleaved-caspase-1 (D210) detects levels of fragment of activated Caspase-1 protein resulting from cleavage adjacent to D210.

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$ 265.00
Cat# ABV11663
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