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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Phospho-Bcl-2 (Ser70) Antibody   

Phospho-Bcl-2 (Ser70) Antibody

Purified Rabbit Polyclonal Antibody

  • WB - Phospho-Bcl-2 (Ser70) Antibody ABV11670
    Western blot analysis in Hela cell line lysates.
  • WB - Phospho-Bcl-2 (Ser70) Antibody ABV11670
    Western blot analysis in Vascula Endothelial cell line lysates. Bcl-2 was detected using the Phospho-Bcl-2(Ser70) Polyclonal purified antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P10415
Reactivity Human, Monkey
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 26266 Da
Additional Information
Gene ID 596
Other Names BCL2; Apoptosis regulator Bcl-2
Target/Specificity Bcl2 (Ser70)
Format 100 ug (1mg/ml) of antibody in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Handling The antibody solution should be gently mixed before use
Background Descriptions
PrecautionsPhospho-Bcl-2 (Ser70) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCL2
Function Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Cellular Location Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein
Tissue Location Expressed in a variety of tissues.
Research Areas
Citations (0)

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Bcl2 is an integral outer mitochondrial membrane protein that regulates the apoptotic cell death in variety of cells such as lymphocytes and neural cells. It regulates mitochondrial calcium homeostasis and proton flux. Several reports suggested that these phosphorylation sites may be targets of the ASK1/MKK7/JNK1 pathway and that phosphorylation of Bcl-2 may be a marker for mitotic events. Interleukin-3 and JNK-induced Bcl-2 phosphorylation at Ser70 regulates anti-apoptotic activity.

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$ 285.00
Cat# ABV11670
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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