|Application ||WB, IHC, IF|
|Other Accession||O08738 (Mouse), O35397 (Rat)|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||33310 Da|
|Other Names||CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2|
|Formulation||100ug (1mg/ml) of antibody in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide|
|Handling||The antibody solution should be gently mixed before use|
|Precautions||Phospho-Caspase-6 (Ser257) antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.|
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Provided below are standard protocols that you may find useful for product applications.
Caspases are the central components of the apoptotic response. Caspase 6 is a member of the cysteine-aspartic acid protease (caspase) family. Caspases are divided into two classes: the initiator caspases, which include caspase 2, 8, 9 and 10 and the effector caspases, which include caspases 3, 6 and 7. Effector caspases being activated by initiator caspases leads the proteolytic cleavage of a broad spectrum of cellular targets, which ultimately leads to cell death.
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