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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Phospho-Bcl-x (Thr47) antibody   

Phospho-Bcl-x (Thr47) antibody

Purified Rabbit Polyclonal Antibody

  • WB - Phospho-Bcl-x (Thr47) antibody ABV11673
    Western blot analysis of R.muscle cells lysate using Phospho-Bcl-x(Thr47) antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q07817
Other Accession Q64373 (Mouse), P53563 (Rat)
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 26049 Da
Additional Information
Gene ID 598
Other Names BCL2L1; BCL2L; BCLX; Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X
Target/Specificity Bcl-x (Thr47)
Format 100 ug (1mg/ml) of antibody in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Handling The antibody solution should be gently mixed before use
Background Descriptions
PrecautionsPhospho-Bcl-x (Thr47) antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCL2L1
Synonyms BCL2L, BCLX
Function Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(S) promotes apoptosis.
Cellular Location Isoform Bcl-X(L): Mitochondrion inner membrane. Mitochondrion outer membrane. Mitochondrion matrix. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side. Note=After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity). Localizes to the centrosome when phosphorylated at Ser-49.
Tissue Location Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain
Research Areas
Citations (0)

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Bcl-x is a dominant regulator of programmed cell death in mammalian cells. Members of the wider Bcl-2 family, which also includes Bcl-x, Bcl-w and Mcl-1, are described by their similarity to Bcl-2 protein. Bcl-x an antiapoptotic member of the Bcl-2 family is a dominant regulator of programmed cell death in mammalian cells. Bcl-x is located at the outer mitochondrial membrane and regulates outer mitochondrial membrane channel (VDAC) opening. The long form (Bcl-x (L)) displays cell death repressor activity, but the short isoform (Bcl-x(S)) and the b-isoform (Bcl-xb) promote cell death.

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$ 285.00
Cat# ABV11673
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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