|Application ||WB, FC, E|
|Calculated MW||25416 Da|
|Other Names||CD9 antigen, 5H9 antigen, Cell growth-inhibiting gene 2 protein, Leukocyte antigen MIC3, Motility-related protein, MRP-1, Tetraspanin-29, Tspan-29, p24, CD9, CD9, MIC3, TSPAN29|
|Formulation||1 mg/ml in phosphate buffered saline (PBS) with sodium azide (15 mM), Approx. pH: 7.4.|
|Handling||The antibody solution should be gently mixed before use|
|Precautions||Anti-human CD9 antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion.|
|Cellular Location||Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
|Tissue Location||Detected in platelets (at protein level). Expressed by a variety of hematopoietic and epithelial cells|
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Provided below are standard protocols that you may find useful for product applications.
Anti-CD9 recognizes a human 24-kiloDalton (kDa) single-chain cell-surface glycoprotein (p24) belonging to the tetraspanin family which transverse the membrane four times. The CD9 antigen has a very broad tissue distribution. It is present on basophils, eosinophils, monocytes, pre-B cells, B cells, and various leukemic cell lines (erythroid, myeloid, some T-lymphoid, pre–B-lymphoid). It is also found on follicular center cells, sinus histocytes, macrophages, Kupffer cells, osteoclasts, hepatocytes, bile duct endothelium, renal glomeruli, proximal and distal tubuli, epithelia (intercellular spinous spaces) of skin and mucosa, fibroblasts, connective tissue, endothelium, smooth muscle, cardiac muscle, synovial lining cells, brain white matter, peripheral nerves and human keratin. In addition to being a co-stimulatory molecule, CD9 antigen activates platelets and induces mitogenesis and kinase activity and is involved in cell migration, cell adhesion, and integrin signaling.
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