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Anti-human CD63 antibody

Purified Mouse Monoclonal Antibody

  • E - Anti-human CD63 antibody ABV11681
    CD63 detection in purified exosomes from cell supernatants (COLO1-30, MM1-30, BLCL21-30).
  • FC - Anti-human CD63 antibody ABV11681
    CD63 staining of human plasma purified exosomes.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08962
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG1
Calculated MW 25637 Da
Additional Information
Gene ID 967
Other Names CD63 antigen, Granulophysin, Lysosomal-associated membrane protein 3, LAMP-3, Melanoma-associated antigen ME491, OMA81H, Ocular melanoma-associated antigen, Tetraspanin-30, Tspan-30, CD63, CD63, MLA1, TSPAN30
Target/Specificity CD63 (unconjugated)
Format 1 mg/ml in phosphate buffered saline (PBS) with sodium azide (15 mM), Approx. pH: 7.4.
Handling The antibody solution should be gently mixed before use
Background Descriptions
PrecautionsAnti-human CD63 antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD63
Synonyms MLA1, TSPAN30
Function Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
Cellular Location Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endosome, multivesicular body. Melanosome. Note=Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules. Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies
Tissue Location Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages
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Anti-CD63 recognizes an extracellular fragment of CD63, a 56-kilodalton (kDa), type III lysosomal glycoprotein, belonging to the tetraspanin family. CD63 is expressed by granulocytes, platelets, T-cells, monocytes/macrophages, endothelial cells. CD63 protein is also expressed in exosome membrane. Cell sur-face exposition of CD63 is usually activation dependent. CD63 interacts with integrins and affects phagocytosis and cell migration, it is also involved in H/K ATPase trafficking regulation of ROMK1 channels. CD63 also serves as a T-cell co-stimulator molecule. Expression of CD63 can be used for predicting the prognosis in earlier stages of carcinomas.

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$ 365.00
Cat# ABV11681
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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