|Application ||WB, FC, E|
|Calculated MW||25809 Da|
|Other Names||CD81 antigen, 26 kDa cell surface protein TAPA-1, Target of the antiproliferative antibody 1, Tetraspanin-28, Tspan-28, CD81, CD81, TAPA1, TSPAN28|
|Formulation||1 mg/ml in phosphate buffered saline (PBS) with sodium azide (15 mM), Approx. pH: 7.4.|
|Handling||The antibody solution should be gently mixed before use|
|Precautions||Anti-human CD81 antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines|
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Provided below are standard protocols that you may find useful for product applications.
CD81 (TAPA1), a member of the tetraspanin family, is virtually expressed on all nucleated cells, but in particular on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins and co-receptors. In muscles, CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus.
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