|Application ||WB, E, IP|
|Calculated MW||81538 Da|
|Other Names||CD44 antigen, CDw44, Epican, Extracellular matrix receptor III, ECMR-III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1, PGP-1, Phagocytic glycoprotein I, PGP-I, CD44, CD44, LHR, MDU2, MDU3, MIC4|
|Format||1 mg/ml in phosphate buffered saline (PBS) with sodium azide (15 mM), Approx. pH: 7.4.|
|Handling||The antibody solution should be gently mixed before use|
|Precautions||Anti-human CD44 antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||LHR, MDU2, MDU3, MIC4|
|Function||Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with actin in membrane protrusions at wounding edges.|
|Tissue Location||Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas Expression is repressed in neuroblastoma cells|
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Provided below are standard protocols that you may find useful for product applications.
CD44, known also as HCAM, is a 742 amino acids protein involved in hematopoiesis, lymphocytes activation. CD44 is expressed in multiple isoforms. In particular, CD44 is highly expressed in cancer tissues and tumor-derived exosomes, suggesting a role in tumor progression and metastasis.
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