Anti-human TM9SF4 antibody
Purified Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, FC |
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Primary Accession | Q92544 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 74519 Da |
Gene ID | 9777 |
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Other Names | Transmembrane 9 superfamily member 4, TM9SF4, KIAA0255 |
Target/Specificity | TM9SF4 (unconjugated) |
Formulation | 0.5 mg/ml in Glycine (0.1 M), NaCl (0.5 M), Tris-HCl (0.1 M), Sodium Azide (15 mM), pH: 7. |
Handling | The antibody solution should be gently mixed before use |
Background Descriptions | |
Precautions | Anti-human TM9SF4 antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TM9SF4 |
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Synonyms | KIAA0255, TUCAP1 {ECO:0000303|PubMed:198 |
Function | Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface (PubMed:25999474). Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells (PubMed:25659576). Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells (PubMed:19893578). |
Cellular Location | Membrane; Multi-pass membrane protein. Golgi apparatus Early endosome |
Tissue Location | Highly expressed in metastatic melanoma cells whereas it is undetectable in primary melanoma cells, healthy skin tissues and peripheral blood lymphocytes. Expressed in CD34(+) hematopoietic progenitor cells and during monocyte and granulocyte differentiation. Overexpressed in acute myeloid leukemia, in particular in those displaying granulocytic differentiation (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
TM9SF4 (TUCAP1) is a new tumor associated protein that belongs to the Trans-Membrane 9 Superfamily (TM9SF), a family of proteins with unknown function. These proteins are characterized by the presence of a large variable extracellular N-terminal domain followed by nine putative transmembrane domains in the conserved C terminal domain. TM9SF4 resulted expressed in exosomes derived principally from tumoral source.
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