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Anti-human TM9SF4 antibody

Purified Rabbit Polyclonal Antibody

     
  • IHC - Anti-human TM9SF4 antibody ABV11692
    Immunohistochemical staining of TM9SF4 in specimens derived from healthy colon.
  • WB - Anti-human TM9SF4 antibody ABV11692
    Detection of TM9Sf4 by Western blot. 1.HEK293 cell lysate(20ug); 2.MM1 cell supernatant purified exosomes(20ug); 3.Plasma of healthy donors purified exosomes(20ug).
  • FC - Anti-human TM9SF4 antibody ABV11692
    Purified exosomes from MM1 cell line detected by TM9SF4 antibody.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, FC
Primary Accession Q92544
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 74519 Da
Additional Information
Gene ID 9777
Other Names Transmembrane 9 superfamily member 4, TM9SF4, KIAA0255
Target/Specificity TM9SF4 (unconjugated)
Format 0.5 mg/ml in Glycine (0.1 M), NaCl (0.5 M), Tris-HCl (0.1 M), Sodium Azide (15 mM), pH: 7.
Handling The antibody solution should be gently mixed before use
Background Descriptions
PrecautionsAnti-human TM9SF4 antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TM9SF4
Synonyms KIAA0255, TUCAP1 {ECO:0000303|PubMed:198
Function Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface (PubMed:25999474). Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells (PubMed:25659576). Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells (PubMed:19893578).
Cellular Location Membrane; Multi-pass membrane protein. Golgi apparatus. Early endosome
Tissue Location Highly expressed in metastatic melanoma cells whereas it is undetectable in primary melanoma cells, healthy skin tissues and peripheral blood lymphocytes. Expressed in CD34(+) hematopoietic progenitor cells and during monocyte and granulocyte differentiation. Overexpressed in acute myeloid leukemia, in particular in those displaying granulocytic differentiation (at protein level).
Citations (0)

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Background

TM9SF4 (TUCAP1) is a new tumor associated protein that belongs to the Trans-Membrane 9 Superfamily (TM9SF), a family of proteins with unknown function. These proteins are characterized by the presence of a large variable extracellular N-terminal domain followed by nine putative transmembrane domains in the conserved C terminal domain. TM9SF4 resulted expressed in exosomes derived principally from tumoral source.

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$ 365.00
Cat# ABV11692
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