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CD223 (LAG3) Polyclonal Antibody

Rabbit Anti Human Polyclonal Antibody

     
  • FC - CD223 (LAG3) Polyclonal Antibody ABV11713-100
    Lane1: K562 cell line lysates; Lane2: Human ovary lysate; Lane3:Mouse liver lysate; Lane4: A2058 whole cell lysate
    detail
  • WB - CD223 (LAG3) Polyclonal Antibody ABV11713-100
    Overlay histogram showing Jurkat cells stained with LAG 3 antibody(red line).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, FC
Primary Accession P18627
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 57449 Da
Additional Information
Gene ID 3902
Positive Control IHC, FC, WB
Application & Usage IHC-P: 1:10~50, FC: 1:25, WB: 1:1000
Other Names Lymphocyte activation gene 3 protein, LAG-3, Protein FDC, CD223, LAG3, FDC
Target/Specificity LAG3
Antibody Form Liquid
Appearance Colorless liquid
Formulation PBS with 0.09% (W/V) sodium azide.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsCD223 (LAG3) Polyclonal Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LAG3 (HGNC:6476)
Synonyms FDC
Function Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648). Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity). FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity). Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1 (By similarity). Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648). Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function (By similarity). Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation (By similarity). Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear (PubMed:8647185).
Cellular Location [Lymphocyte activation gene 3 protein]: Cell membrane; Single-pass type I membrane protein
Tissue Location Primarily expressed in activated T-cells and a subset of natural killer (NK) cells.
Research Areas
Citations (0)
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Background

Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. Involved in lymphocyte activation. Binds to HLA class-II antigens.

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Discontinued
Cat# ABV11713-100
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