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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PVR/CD155 Polyclonal Antibody   

PVR/CD155 Polyclonal Antibody

Rabbit Anti Human Polyclonal Antibody

  • WB - PVR/CD155 Polyclonal Antibody ABV11717
    Western blot analysis of PVR in K562 cell line lysate.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P15151
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 45303 Da
Additional Information
Gene ID 5817
Positive Control WB
Application & Usage WB: 1:1000
Other Names Poliovirus receptor, Nectin-like protein 5, NECL-5, CD155, PVR, PVS
Target/Specificity PVR
Antibody Form Liquid
Appearance Colorless liquid
Formulation PBS with 0.09% (W/V) sodium azide.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsPVR/CD155 Polyclonal Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PVR
Synonyms PVS
Function Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.
Cellular Location Isoform Alpha: Cell membrane; Single-pass type I membrane protein Isoform Beta: Secreted.
Research Areas
Citations (0)

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The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.

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$ 155.00
Cat# ABV11717
(40 western blots)
Availability: 5-7days
Bulk Size
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