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PVR/CD155 Polyclonal Antibody
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P15151 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 45303 Da |
| Gene ID | 5817 |
|---|---|
| Positive Control | WB |
| Application & Usage | WB: 1:1000 |
| Other Names | Poliovirus receptor, Nectin-like protein 5, NECL-5, CD155, PVR, PVS |
| Target/Specificity | PVR |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | PBS with 0.09% (W/V) sodium azide. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | PVR/CD155 Polyclonal Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PVR |
|---|---|
| Synonyms | PVS |
| Function | Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. |
| Cellular Location | [Isoform Alpha]: Cell membrane; Single-pass type I membrane protein [Isoform Beta]: Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.
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