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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TLR2 Polyclonal Antibody    

TLR2 Polyclonal Antibody

Rabbit Anti Human Polyclonal Antibody

  • FC - TLR2 Polyclonal Antibody  ABV11721
    Flow cytometric analysis of CEM cells using TLR2 antibody(N-term)(bottom histogram) compared to a negative control cell(top histogram).
  • IHC - TLR2 Polyclonal Antibody  ABV11721
    Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with TLR2 antibody(N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
  • WB - TLR2 Polyclonal Antibody  ABV11721
    Western blot analysis of TLR2 antibody in Ramos cell line lysates.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O60603
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 89838 Da
Additional Information
Gene ID 7097
Positive Control WB, IHC-P, FC
Application & Usage WB~~1:1000, IHC-P~~1:10~50, FC~~1:10~5
Other Names Toll-like receptor 2, Toll/interleukin-1 receptor-like protein 4, CD282, TLR2, TIL4
Target/Specificity TLR2
Antibody Form Liquid
Appearance Colorless liquid
Formulation PBS with 0.09% (W/V) sodium azide.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsTLR2 Polyclonal Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TLR2
Synonyms TIL4
Function Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.

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$ 155.00
Cat# ABV11721
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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