CD28 Polyclonal Antibody
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | P10747 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 25066 Da |
Gene ID | 940 |
---|---|
Positive Control | WB, ELISA |
Application & Usage | Western Blot: 1:500 – 1:2000, ELISA: 1:20000. |
Other Names | CD28; T-cell-specific surface glycoprotein CD28; TP44; CD28 |
Target/Specificity | CD28 |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | CD28 Polyclonal Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CD28 |
---|---|
Function | Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). |
Cellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Location | Expressed in T-cells and plasma cells, but not in less mature B-cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
Involved in T-cell activation, induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells.
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