|Application ||WB, E|
|Calculated MW||25066 Da|
|Positive Control||WB, ELISA|
|Application & Usage||Western Blot: 1:500 – 1:2000, ELISA: 1:20000.|
|Other Names||CD28; T-cell-specific surface glycoprotein CD28; TP44; CD28|
|Formulation||PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||CD28 Polyclonal Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in T-cells and plasma cells, but not in less mature B-cells|
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Provided below are standard protocols that you may find useful for product applications.
Involved in T-cell activation, induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells.
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