|Application ||WB, IHC, IF|
|Calculated MW||32834 Da|
|Positive Control||WB: Jurkat cell lysate; IHC: human intestine tissue; IF; human instetine tissue|
|Application & Usage||WB: 1-2 µg/ml; IHC: 2.5 µg/ml; IF: 20 µg/ml|
|Other Names||BTLA, CD272|
|Formulation||PBS with 0.09% (W/V) sodium azide.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||BTLA Polyclonal Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The B- and T-lymphocyte attenuator (BTLA) protein is a member of the immunoglobulin superfamily containing a single immunoglobulin (Ig) domain. Like other coihibitory receptors such as CTLA-4 and PD-1, BTLA functions as a receptor that relays inhibitory signals to suppress the immune response, and can inhibit LPS-induced endotoxic shock by suppressing TLR4 signaling in innate immune cells. Polymorphisms in this gene have also been associated with an increased risk of rheumatoid arthritis
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