|Application ||WB, IHC, E|
|Calculated MW||35924 Da|
|Application & Usage||ELISA: 1-5 µg/ml (Detection sensitivity 10 ng/ml), Immunocytochemistry: 5~10 µg/ml, Western Blot|
|Other Names||cTnT, TNNT2|
|Formulation||100 ug (1mg/ml) of antibody in 0.01M Tris-HCl, pH 8.0, 0.15M NaCl, and 0.02% sodium azide.|
|Reconstitution & Storage||-20 °C|
|Precautions||Troponin T Monoclonal Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.|
|Tissue Location||Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart|
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The protein encoded by TNNT2 is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined.
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