EDG4 Antibody (NT)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC |
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Primary Accession | Q9HBW0 |
Reactivity | Human, Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 38741 Da |
Positive Control | Western blot, IHC |
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Application & Usage | WB: 1:1000, IHC: 1:50~100 |
Alias Symbol | EDG4 |
Other Names | Lysophosphatidic acid receptor 2, LPA receptor 2, LPA-2, Lysophosphatidic acid receptor Edg-4, LPAR2, EDG4, LPA2 |
Appearance | Colourless liquid |
Formulation | 100 µg (0.5 mg/ml) of antibody in PBS with 0.09% (W/V) sodium azide. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | EDG4 Antibody (NT) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | LPAR2 (HGNC:3168) |
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Synonyms | EDG4, LPA2 |
Function | Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation. |
Cellular Location | Cell surface. Cell membrane; Multi-pass membrane protein. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles |
Tissue Location | Expressed most abundantly in testes and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon |
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Provided below are standard protocols that you may find useful for product applications.
Background
EDG4 is a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. It plays a key role in phospholipase C-beta (PLC-beta) signaling pathway and stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.
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