|Application ||WB, IHC, IF|
|Reactivity||Human, Mouse, Rat|
|Positive Control||WB, IHC, IF|
|Application & Usage||WB-1 µg/ml, IHC-P-2.5 µg/ml, IF- 20 µg/ml|
|Other Names||CRTH2 Antibody: DP2, DL1R, CD294, CRTH2, GPR44, Prostaglandin D2 receptor 2, Chemoattractant receptorhomologous molecule expressed on Th2 cells|
|Formulation||50 µg (1mg/ml) of antibody in PBS containing 0.02% sodium azide.|
|Reconstitution & Storage||-20 °C|
|Precautions||CRTH2 Polyclonal Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) is a recently identified receptor for the prostaglandin D2 (PGD2) in addition to the classic prostaglandin D receptor. CRTH2 is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, CRTH2-null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the CRTH2-null mice produced significantly higher amounts of interleukin-5 (IL-5) and IL-3. This suggests that CRTH2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo.
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