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Anti-CD11a (Efalizumab), Human IgG1 Antibody

     
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Product Information
Primary Accession P20701
Reactivity Human
Host Recombinant
Clonality Monoclonal
Isotype Human IgG1, kappa
Calculated MW 128770 Da
Additional Information
Gene ID 3683
Alias Symbol ITGAL
Other Names LFA-1; integrin alpha L
Appearance Colorless liquid
Formulation 200 µg affinity purified human antibody in phosphate-buffered saline (PBS) containing 0.02% Proclin 300
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsAnti-CD11a (Efalizumab), Human IgG1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ITGAL (HGNC:6148)
Synonyms CD11A
Function Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R (PubMed:11812992, PubMed:15528364). Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Leukocytes.
Research Areas
Citations (0)
citation

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Background

Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.

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Discontinued
Cat# ABV11783-200
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