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Anti-alpha 5 beta 1 Integrin (Volociximab), Human IgG4 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, IF, FC, E |
|---|---|
| Primary Accession | P08648 |
| Reactivity | Human |
| Host | Recombinant |
| Clonality | Monoclonal |
| Isotype | Human IgG4, kappa |
| Calculated MW | 114536 Da |
| Gene ID | 3678 |
|---|---|
| Alias Symbol | ITGA5 |
| Other Names | Fibronectin receptor; CD49 antigen-like family member E; Integrin alpha-F; VLA-5; CD49e |
| Appearance | Colorless liquid |
| Formulation | 200 µg affinity purified human antibody in phosphate-buffered saline (PBS) containing 0.02% Proclin 300 |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Anti-alpha 5 beta 1 Integrin (Volociximab), Human IgG4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ITGA5 (HGNC:6141) |
|---|---|
| Synonyms | FNRA |
| Function | Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1 (PubMed:33962943). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Cell junction, focal adhesion |
| Tissue Location | Expressed in placenta (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The antibody binds specifically to a5ß1 integrin, which is part of the superfamily of glycoprotein transmembrane receptors for ligands such as fibronectin, vitronectin, laminins and collagens. The a5ß1 integrin receptor plays a key role in cellular processes such as inflammation, cell proliferation, angiogenesis and tumour metastasis. Comprising the variable domain of the original mouse antibody, a chimeric mouse:human IgG4 version of this antibody has been tested in vivo: In cynomolgus monkeys with laser-induced choroidal neovascularization (CNV), in rabbit models and in human volunteers. The antibody reached Phase II clinical trials with PDL Biopharma and Biogen-Idec.
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