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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Anti-alpha 5 beta 1 Integrin (Volociximab), Human IgG4 Antibody   

Anti-alpha 5 beta 1 Integrin (Volociximab), Human IgG4 Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC, IF, FC, E
Primary Accession P08648
Reactivity Human
Host Recombinant
Clonality Monoclonal
Isotype Human IgG4, kappa
Calculated MW 114536 Da
Additional Information
Gene ID 3678
Alias Symbol ITGA5
Other Names Fibronectin receptor; CD49 antigen-like family member E; Integrin alpha-F; VLA-5; CD49e
Appearance Colorless liquid
Formulation 200 µg affinity purified human antibody in phosphate-buffered saline (PBS) containing 0.02% Proclin 300
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsAnti-alpha 5 beta 1 Integrin (Volociximab), Human IgG4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ITGA5
Synonyms FNRA
Function Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881).
Cellular Location Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion. Cell surface
Research Areas
Citations (0)

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Background

The antibody binds specifically to a5ß1 integrin, which is part of the superfamily of glycoprotein transmembrane receptors for ligands such as fibronectin, vitronectin, laminins and collagens. The a5ß1 integrin receptor plays a key role in cellular processes such as inflammation, cell proliferation, angiogenesis and tumour metastasis. Comprising the variable domain of the original mouse antibody, a chimeric mouse:human IgG4 version of this antibody has been tested in vivo: In cynomolgus monkeys with laser-induced choroidal neovascularization (CNV), in rabbit models and in human volunteers. The antibody reached Phase II clinical trials with PDL Biopharma and Biogen-Idec.

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$ 595.00
Cat# ABV11786-200
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